Panacea Pharmaceuticals, Inc. Raises $8.9 Million in Series D Round
of Financing
June 12, 2006– Gaithersburg, Maryland – Panacea Pharmaceuticals,
Inc., a company focused on developing therapeutic and diagnostic
products for cancer, announced today that it has closed its Series
D Private Placement
raising $8.9 million. Participants in the round included Konishi
Hiroshi; Kenso Kogyo Co., Ltd.; Kyokuto Securities Co., Ltd.;
Medikit Co., Ltd.;
Mizuho Capital Co., Ltd.; Nomura Research & Advisory Co., Ltd.; Shin
Nihon Jitsugyo Co., Ltd.; and SOFTBANK INVESTMENT CORPORATION.
Proceeds from the offering will be used to move potential diagnostic
and therapeutic products within the Company’s HAAH Oncology Program
towards clinical-stage development, as well as strengthen the Company’s
pipeline.
“Our HAAH cancer program is poised to enter several clinical studies
during 2006. Therefore, we welcome the excellent new investors and their
commitment to the long-term support of Panacea and its programs,” stated
Hossein A. Ghanbari, PhD, CEO and Chief Scientific Officer of the Company.
Background on HAAH Oncology Program
The Company’s HAAH Oncology Program is based on the enzyme human
aspartyl (asparaginyl) beta-hydroxylase (HAAH). HAAH over-expression has
been detected in primary tumor tissue of more than twenty tumor types
tested to date, including cancers of the pancreas, breast, ovary, liver,
colon, prostate, lung, brain, and bile duct. HAAH over-expression has
been detected in 99% of tumor specimens (greater than 1000) tested to
date and has not been detected in normal or adjacent non-affected tissue.
Preclinical studies have indicated that over-expression of HAAH is sufficient
to induce cellular transformation, to increase cell motility and invasiveness,
and to establish tumor formation in animals. The HAAH protein is expressed
on the surface of cancer cells and in the periphery of tumors facilitating
an antibody-based treatment approach. In in vitro studies, anti-HAAH antibodies
have been shown to have a beneficial effect on tumor cells, causing them
to revert to a more normal phenotype as measured by the inhibition of
growth, motility, and invasiveness. Besides their direct biological effect
the antibodies are internalized after binding to HAAH and may be used
to specifically deliver cytotoxic agents to tumor cells. Recent studies
have investigated the efficacy of anti-HAAH antibodies in vivo and have
indicated that the murine forms of these antibodies are capable of inhibiting
tumor formation and growth in a xenograft model of primary human liver
cancer. Furthermore these antibodies significantly reduced the number
and size of metastases in an animal model of human colon cancer metastasis
to the liver.
The Company is actively pursuing the development of anti-HAAH antibodies
as novel agents for the treatment of cancer, with liver cancer as its
first intended indication. Recently the Company has engineered high affinity,
fully human anti-HAAH antibodies which display properties in vitro equivalent
to their murine counterparts. These fully human anti-HAAH antibodies are
expected to be the final drug product. The Company is exploring the utility
of both naked anti-HAAH antibodies, as well as antibody conjugates with
various chemotherapeutic agents as lead candidates in this regard.
The Company also maintains an active diagnostic development program based
on anti-HAAH antibodies. The Company has developed a simple blood test
to detect the presence of HAAH in the patient sera. This assay has been
demonstrated to display an exquisite sensitivity and specificity for cancer
and has great potential utility in the diagnosis and management of disease.
The company is poised to initiate clinical trials of this assay for the
screening of individuals at high risk for prostate as well as for liver
cancers.
The confluence of our HAAH-based diagnostic and therapeutic programs
presents a fully integrated approach to cancer treatment and management
(companion diagnostics or theranostics).
About Panacea Pharmaceuticals, Inc.
Panacea Pharmaceuticals, Inc. is an emerging biopharmaceutical company
focused on using functional genomics and proteomics to develop therapeutics
and diagnostics for diseases with substantial unmet clinical need. The
Company’s product development focus is on novel proteins and biochemical
pathways related to cellular regulation and cell cycle abnormalities in
oncology as well as both acute and chronic neurodegenerative conditions
such as hypoxia-induced cognitive impairment, Parkinson’s disease,
and Alzheimer’s disease.
More information about the Company is available at http://www.PanaceaPharma.com.
Except for historical information presented in this press release, matters
discussed herein may constitute “forward-looking statements” within
the meaning of the Private Securities Litigation Reform Act of 1995. Forward-looking
statements are based on the opinions and estimates of management only
as of the date of this release and are subject to certain risks and uncertainties
that could cause actual results to differ materially from any future results,
performance, or achievements expressed or implied by such statements.
Factors that might cause such a difference include, but are not limited
to, uncertainties related to our access to capital, the progress, costs,
and results of any clinical trials undertaken by us, progress of our research
and development projects, and uncertainties related to whether our product
candidates would ultimately achieve commercial success. We do not undertake
any obligation to update publicly any forward-looking statement, whether
as a result of new information, future events, or otherwise unless required
by law.
Contact:
Panacea Pharmaceuticals, Inc.
Kasra Ghanbari
Phone 240-243-8000 x107; FAX 240-465-0450
Kasra@PanaceaPharma.com